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XE 991 dihydrochloride

CAS No. 122955-13-9

XE 991 dihydrochloride( XE-991 | XE991 )

Catalog No. M10900 CAS No. 122955-13-9

A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    XE 991 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.
  • Description
    A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively; displays 14-fold less potency for KCNQ1+minK current with Kd of 11 uM, enhances hippocampal ACh release from rat brain slices (EC50=490 nM) and is a cognitive enhancer in vivo.Alzheimer Disease Discontinued.
  • In Vitro
    XE991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action.
  • In Vivo
    ——
  • Synonyms
    XE-991 | XE991
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    122955-13-9
  • Formula Weight
    449.37
  • Molecular Formula
    C26H20N2O.2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 11.11 mg/mL (24.72 mM)
  • SMILES
    O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
  • Chemical Name
    10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30. 2. Wang HS, et al. Mol Pharmacol. 2000 Jun;57(6):1218-23. 3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct;60(4):753-60. 4. Yeung SY, et al. Br J Pharmacol. 2005 Oct;146(4):585-95.
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